| Saturday 23rd September 2017 | Premier Division | ||
| 15:00 | Barnoldswick Town v Bootle | Silentnight Stadium | |
| 15:00 | Runcorn Linnets v Abbey Hey | Millbank Linnets Stadium | |
| Saturday 23rd September 2017 | First Division | ||
| 15:00 | AFC Blackpool v Cammell Laird 1907 | Mechanics Ground | |
| 15:00 | Cheadle Town v FC Oswestry Town | Park Road Stadium | |
| 15:00 | Eccleshall v Abbey Hulton United | Pershall Park | |
| 15:00 | Holker Old Boys v Daisy Hill | Rakesmoor | |
| 15:00 | New Mills v Atherton LR | Church Lane | |
| 15:00 | St Helens Town v Prestwich Heys | Ruskin Drive Sportsground | |
| Sunday 24th September 2017 | The Buildbase FA Vase 2nd Qual Rnd | ||
| 15:00 | 1874 Northwich v Congleton Town | St Luke`s Barton Stadium | |
| Monday 25th September 2017 | Premier Division | ||
| 19:45 | Maine Road v Abbey Hey | Brantingham Road | |
| Monday 25th September 2017 | Lancashire Challenge Trophy 1st Rnd | ||
| 19:45 | Squires Gate v Radliffe Borough | The Brian Addison Stadium | |
| Tuesday 26th September 2017 | Premier Division | ||
| 19:45 | Ashton Athletic v Barnton | Brocstedes Park | |
| Tuesday 26th September 2017 | First Division | ||
| 19:45 | Chadderton v New Mills | ARK Fleetech Stadium | |
| Tuesday 26th September 2017 | Lancashire Challenge Trophy 1st Rnd | ||
| 19:45 | West Didsbury & Chorlton v Nelson | The Recreation Ground | |
| Wednesday 27th September 2017 | Premier Division | ||
| 19:45 | AFC Darwen v Runcorn Linnets | WEC Group Anchor Ground | |
| Saturday 30th September 2017 | The Emirates F.A Cup 3rd Qual Rnd | ||
| 15:00 | 1874 Northwich v Ossett Town | St Luke`s Barton Stadium | |
| 12:30 | Ashton Athletic v Chorley | Brocstedes Park | |
| Saturday 30th September 2017 | Premier Division | ||
| 15:00 | Abbey Hey v Winsford United | The Abbey Stadium | |
| 15:00 | Barnton v Padiham | Townfield | |
| 15:00 | Burscough v Irlam | Victoria Park | |
| 15:00 | Charnock Richard v Bootle | Mossie Park | |
| 15:00 | City of Liverpool FC v Barnoldswick Town | TDP Solicitors Stadium | |
| 15:00 | Hanley Town v AFC Liverpool | Potteries Park | |
| 15:00 | Maine Road v Northwich Victoria | Brantingham Road | |
| 15:00 | Runcorn Town v Congleton Town | Pavilions | |
| 15:00 | Squires Gate v Runcorn Linnets | The Brian Addison Stadium | |
| Saturday 30th September 2017 | First Division | ||
| 15:00 | Bacup Borough v Cheadle Town | Brian Boys West View Stadium | |
| 15:00 | Cammell Laird 1907 v Atherton LR | Kirklands | |
| 15:00 | Carlisle City v Alsager Town | Gillford Park Stadium, | |
| 15:00 | Chadderton v Holker Old Boys | ARK Fleetech Stadium | |
| 15:00 | Daisy Hill v St Helens Town | New Sirs | |
| 15:00 | FC Oswestry Town v Litherland REMYCA | The Venue | |
| 15:00 | Nelson v Eccleshall | Little Wembley | |
| 15:00 | Prestwich Heys v Abbey Hulton United | Adie Moran Park | |
| 15:00 | Sandbach United v AFC Blackpool | Sandbach Community Football Centre | |
| 15:00 | Stockport Town v Silsden | Lambeth Grove | |
| 15:00 | Whitchurch Alport v New Mills | Yockings Park | |
| Monday 2nd October 2017 | Premier Division | ||
| 19:45 | Widnes v City of Liverpool FC | Select Security Stadium | |
| 19:45 | Winsford United v Runcorn Town | St Luke`s Barton Stadium | |
| Tuesday 3rd October 2017 | Premier Division | ||
| 19:45 | Congleton Town v Irlam | Richborough Estates Stadium | |
| 19:45 | Northwich Victoria v 1874 Northwich | Townfield | |
| 19:45 | Squires Gate v Padiham | The Brian Addison Stadium | |
| 19:45 | West Didsbury & Chorlton v Burscough | The Recreation Ground | |
| Tuesday 3rd October 2017 | First Division | ||
| 19:45 | Abbey Hulton United v Sandbach United | Birches Head Road | |
| 19:45 | Alsager Town v Cammell Laird 1907 | Woodpark Stadium | |
| 19:45 | Carlisle City v Nelson | Gillford Park Stadium, | |
| 19:45 | Silsden v AFC Blackpool | The Cobbydale Construction Stadium | |
| Wednesday 4th October 2017 | Premier Division | ||
| 19:45 | AFC Darwen v Charnock Richard | WEC Group Anchor Ground | |
| 19:45 | AFC Liverpool v Ashton Athletic | The Marine Travel Arena | |
| 19:45 | Hanley Town v Maine Road | Potteries Park | |
| Saturday 7th October 2017 | Premier Division | ||
| 15:00 | 1874 Northwich v Runcorn Linnets | St Luke`s Barton Stadium | |
| 15:00 | AFC Darwen v Runcorn Town | WEC Group Anchor Ground | |
| 15:00 | AFC Liverpool v Maine Road | The Marine Travel Arena | |
| 15:00 | Barnoldswick Town v Hanley Town | Silentnight Stadium | |
| 15:00 | Bootle v Abbey Hey | TDP Solicitors Stadium | |
| 15:00 | Charnock Richard v Winsford United | Mossie Park | |
| 15:00 | Congleton Town v Ashton Athletic | Richborough Estates Stadium | |
| 15:00 | Irlam v Barnton | The Ambitek Stadium | |
| 15:00 | Northwich Victoria v Widnes | Townfield | |
| 15:00 | Padiham v City of Liverpool FC | YESSS Electrical Arena | |
| 15:00 | West Didsbury & Chorlton v Squires Gate | The Recreation Ground | |
| Saturday 7th October 2017 | First Division | ||
| 15:00 | AFC Blackpool v Abbey Hulton United | Mechanics Ground | |
| 15:00 | Alsager Town v Prestwich Heys | Woodpark Stadium | |
| 15:00 | Atherton LR v Sandbach United | Crilly Park | |
| 15:00 | Bacup Borough v Whitchurch Alport | Brian Boys West View Stadium | |
| 15:00 | Carlisle City v FC Oswestry Town | Gillford Park Stadium, | |
| 15:00 | Cheadle Town v Nelson | Park Road Stadium | |
| 15:00 | Eccleshall v Holker Old Boys | Pershall Park | |
| 15:00 | Litherland REMYCA v New Mills | Litherland Sports Park | |
| 15:00 | Silsden v Cammell Laird 1907 | The Cobbydale Construction Stadium | |
| 15:00 | St Helens Town v Chadderton | Ruskin Drive Sportsground | |
| 15:00 | Stockport Town v Daisy Hill | Lambeth Grove | |
| Monday 9th October 2017 | The LWC Drinks First Division Cup 1st Round North | ||
| 19:45 | Daisy Hill v Litherland REMYCA | New Sirs | |
| Monday 9th October 2017 | Premier Division | ||
| 19:45 | Maine Road v Padiham | Brantingham Road | |
| Tuesday 10th October 2017 | The LWC Drinks First Division Cup 1st Round North | ||
| 19:45 | Atherton LR v Carlisle City | Crilly Park | |
| Tuesday 10th October 2017 | The LWC Drinks First Division Cup 1st Round South | ||
| 19:45 | Chadderton v Cheadle Town | ARK Fleetech Stadium | |
| 19:45 | New Mills v Alsager Town | Church Lane | |
| Tuesday 10th October 2017 | Premier Division | ||
| 19:45 | 1874 Northwich v Congleton Town | St Luke`s Barton Stadium | |
| 19:45 | Abbey Hey v AFC Darwen | The Abbey Stadium | |
| 19:45 | Ashton Athletic v Northwich Victoria | Brocstedes Park | |
| 19:45 | Barnoldswick Town v AFC Liverpool | Silentnight Stadium | |
| 19:45 | Burscough v Winsford United | Victoria Park | |
| 19:45 | City of Liverpool FC v Runcorn Town | TDP Solicitors Stadium | |
| 19:45 | Squires Gate v Bootle | The Brian Addison Stadium | |
| Wednesday 11th October 2017 | The LWC Drinks First Division Cup 1st Round North | ||
| 19:45 | Holker Old Boys v St Helens Town | Rakesmoor | |
| Wednesday 11th October 2017 | The LWC Drinks First Division Cup 1st Round South | ||
| 19:45 | Sandbach United v FC Oswestry Town | Sandbach Community Football Centre | |
| Wednesday 11th October 2017 | Premier Division | ||
| 19:45 | Barnton v Widnes | Townfield | |
| 19:45 | Hanley Town v Runcorn Linnets | Potteries Park | |
| Friday 13th October 2017 | First Division | ||
| 19:45 | Prestwich Heys v Chadderton | Adie Moran Park | |
| Saturday 23rd September 2017 The Buildbase FA Vase 2nd Qual Rnd |
| AFC Liverpool v City of Lpool (15:00) |
| Alsager Town v Nostell MW (15:00) |
| Ashton Athletic v Maltby Main (15:00) |
| Burscough v Armthorpe Welf (15:00) |
| Carlisle City v Thornaby (15:00) |
| Charnock Rich v Bacup Borough (15:00) |
| Dronfield Town v Barnton (15:00) |
| Garforth Town v Nelson (15:00) |
| Glasshoughton v AFC Darwen (15:00) |
| Highgate Utd P-P Whitchurch Alp (15:00) |
| Irlam v Parkgate (15:00) |
| Lith REMYCA v Chadderton (15:00) |
| Padiham P-P Ashington (15:00) |
| Sandbach v AFC Emley (15:00) |
| Studley v Hanley Town (15:00) |
| West Auckland v Silsden (15:00) |
| West Did & Chor v Stockport Town (15:00) |
| Winsford United v Pontefract Col (15:00) |
| Saturday 23rd September 2017 Premier Division |
| Barnoldswick Tn v Bootle (15:00) |
| Runcorn Linnets v Abbey Hey (15:00) |
| Saturday 23rd September 2017 First Division |
| AFC Blackpool v Cammell Laird (15:00) |
| Cheadle Town v FC Oswestry (15:00) |
| Eccleshall v Abbey Hulton (15:00) |
| Holker OB v Daisy Hill (15:00) |
| New Mills v Atherton LR (15:00) |
| St Helens Town v Prestwich Heys (15:00) |
| Sunday 24th September 2017 The Buildbase FA Vase 2nd Qual Rnd |
| 1874 Northwich v Congleton Town (15:00) |
| Monday 25th September 2017 Premier Division |
| Maine Road v Abbey Hey (19:45) |
| Monday 25th September 2017 Lancashire Challenge Trophy 1st Rnd |
| Squires Gate v (19:45) |
| Tuesday 26th September 2017 Premier Division |
| Ashton Athletic v Barnton (19:45) |
| Tuesday 26th September 2017 First Division |
| Chadderton v New Mills (19:45) |
| Tuesday 26th September 2017 Lancashire Challenge Trophy 1st Rnd |
| West Did & Chor v Nelson (19:45) |
| Wednesday 27th September 2017 Premier Division |
| AFC Darwen v Runcorn Linnets (19:45) |
| Saturday 30th September 2017 The Emirates F.A Cup 3rd Qual Rnd |
| 1874 Northwich v Ossett Town (15:00) |
| Ashton Athletic v Chorley (12:30) |
| Saturday 30th September 2017 Premier Division |
| Abbey Hey v Winsford United (15:00) |
| Barnton v Padiham (15:00) |
| Burscough v Irlam (15:00) |
| Charnock Rich v Bootle (15:00) |
| City of Lpool v Barnoldswick Tn (15:00) |
| Hanley Town v AFC Liverpool (15:00) |
| Maine Road v Northwich Vics (15:00) |
| Runcorn Town v Congleton Town (15:00) |
| Squires Gate v Runcorn Linnets (15:00) |
| Saturday 30th September 2017 First Division |
| Bacup Borough v Cheadle Town (15:00) |
| Cammell Laird v Atherton LR (15:00) |
| Carlisle City v Alsager Town (15:00) |
| Chadderton v Holker OB (15:00) |
| Daisy Hill v St Helens Town (15:00) |
| FC Oswestry v Lith REMYCA (15:00) |
| Nelson v Eccleshall (15:00) |
| Prestwich Heys v Abbey Hulton (15:00) |
| Sandbach v AFC Blackpool (15:00) |
| Stockport Town v Silsden (15:00) |
| Whitchurch Alp v New Mills (15:00) |
| Monday 2nd October 2017 Premier Division |
| Widnes v City of Lpool (19:45) |
| Winsford United v Runcorn Town (19:45) |
| Tuesday 3rd October 2017 Premier Division |
| Congleton Town v Irlam (19:45) |
| Northwich Vics v 1874 Northwich (19:45) |
| Squires Gate v Padiham (19:45) |
| West Did & Chor v Burscough (19:45) |
| Tuesday 3rd October 2017 First Division |
| Abbey Hulton v Sandbach (19:45) |
| Alsager Town v Cammell Laird (19:45) |
| Carlisle City v Nelson (19:45) |
| Silsden v AFC Blackpool (19:45) |
| Wednesday 4th October 2017 Premier Division |
| AFC Darwen v Charnock Rich (19:45) |
| AFC Liverpool v Ashton Athletic (19:45) |
| Hanley Town v Maine Road (19:45) |
| Saturday 7th October 2017 Premier Division |
| 1874 Northwich v Runcorn Linnets (15:00) |
| AFC Darwen v Runcorn Town (15:00) |
| AFC Liverpool v Maine Road (15:00) |
| Barnoldswick Tn v Hanley Town (15:00) |
| Bootle v Abbey Hey (15:00) |
| Charnock Rich v Winsford United (15:00) |
| Congleton Town v Ashton Athletic (15:00) |
| Irlam v Barnton (15:00) |
| Northwich Vics v Widnes (15:00) |
| Padiham v City of Lpool (15:00) |
| West Did & Chor v Squires Gate (15:00) |
| Saturday 7th October 2017 First Division |
| AFC Blackpool v Abbey Hulton (15:00) |
| Alsager Town v Prestwich Heys (15:00) |
| Atherton LR v Sandbach (15:00) |
| Bacup Borough v Whitchurch Alp (15:00) |
| Carlisle City v FC Oswestry (15:00) |
| Cheadle Town v Nelson (15:00) |
| Eccleshall v Holker OB (15:00) |
| Lith REMYCA v New Mills (15:00) |
| Silsden v Cammell Laird (15:00) |
| St Helens Town v Chadderton (15:00) |
| Stockport Town v Daisy Hill (15:00) |
| Monday 9th October 2017 The LWC Drinks First Division Cup 1st Round North |
| Daisy Hill v Lith REMYCA (19:45) |
| Monday 9th October 2017 Premier Division |
| Maine Road v Padiham (19:45) |
| Tuesday 10th October 2017 The LWC Drinks First Division Cup 1st Round North |
| Atherton LR v Carlisle City (19:45) |
| Tuesday 10th October 2017 The LWC Drinks First Division Cup 1st Round South |
| Chadderton v Cheadle Town (19:45) |
| New Mills v Alsager Town (19:45) |
| Tuesday 10th October 2017 Premier Division |
| 1874 Northwich v Congleton Town (19:45) |
| Abbey Hey v AFC Darwen (19:45) |
| Ashton Athletic v Northwich Vics (19:45) |
| Barnoldswick Tn v AFC Liverpool (19:45) |
| Burscough v Winsford United (19:45) |
| City of Lpool v Runcorn Town (19:45) |
| Squires Gate v Bootle (19:45) |
| Wednesday 11th October 2017 The LWC Drinks First Division Cup 1st Round North |
| Holker OB v St Helens Town (19:45) |
| Wednesday 11th October 2017 The LWC Drinks First Division Cup 1st Round South |
| Sandbach v FC Oswestry (19:45) |
| Wednesday 11th October 2017 Premier Division |
| Barnton v Widnes (19:45) |
| Hanley Town v Runcorn Linnets (19:45) |
| Friday 13th October 2017 First Division |
| Prestwich Heys v Chadderton (19:45) |
