| Sat 18/08/18 | Maine Road v New Mills | 1-4 | | | | |
| Mon 27/08/18 | Maine Road v St Martins | 3-4 | | | | |
| Sat 01/09/18 | Maine Road v Cheadle Town | 5-1 | | | | |
| Sat 08/09/18 | FC Oswestry Town v Maine Road * | 3-2 | | | | |
| Sat 22/09/18 | Maine Road v Stone Old Alleynians * | 2-3 | | | | |
| Mon 24/09/18 | Stockport Town v Maine Road | 3-0 | | | | |
| Sat 29/09/18 | Alsager Town v Maine Road | 2-0 | |  | | |
| Sat 06/10/18 | Maine Road v FC Oswestry Town | 2-2 | | | | |
| Tue 09/10/18 | Trafford v Maine Road * | 4-0 | | | | |
| Sat 13/10/18 | Barnton v Maine Road | 5-0 | | | | |
| Sat 20/10/18 | Maine Road v Steeton * | 4-0 | | | | |
| Tue 23/10/18 | Cheadle Heath Nomads v Maine Road | 2-1 | | | | |
| Sat 27/10/18 | Ellesmere Rangers v Maine Road | 1-2 | | | | |
| Tue 30/10/18 | Wythenshawe Amateurs v Maine Road | 3-1 | | | | |
| Sat 03/11/18 | Maine Road v Sandbach United * | 0-2 | | | | |
| Sat 24/11/18 | Maine Road v Garstang | 1-1 | | | | |
| Tue 27/11/18 | Stone Old Alleynians v Maine Road | 6-1 | | | | |
| Sat 22/12/18 | Maine Road v Cheadle Heath Nomads | 0-3 | | | | |
| Wed 26/12/18 | Maine Road v Rylands | 0-5 | | | | |
| Sat 05/01/19 | St Martins v Maine Road | 1-2 | | | | |
| Sat 12/01/19 | Maine Road v Cammell Laird 1907 | 3-1 | | | | |
| Sat 09/02/19 | Abbey Hulton United v Maine Road | 3-5 | | | | |
| Sat 16/02/19 | Maine Road v Alsager Town * | 4-0 | | | | |
| Sat 23/02/19 | Maine Road v Wythenshawe Town | 2-3 |  | | | |
| Mon 08/04/19 | Maine Road v Barnton | 1-2 | | | | |
| Sat 13/04/19 | Vauxhall Motors v Maine Road | 3-0 | | | | |
| Tue 16/04/19 | Sandbach United v Maine Road | 5-1 | | | | |
| Sat 20/04/19 | Maine Road v Stone Dominoes | 4-0 | | | | |
