| Sat 04/08/18 | Lower Breck v St Helens Town | 1-2 | | | |  |
| Thu 09/08/18 | St Helens Town v Atherton LR | 3-0 | | | | |
| Sat 11/08/18 | Bacup Borough v St Helens Town | 2-2 | | | | |
| Sat 18/08/18 | St Helens Town v AFC Darwen | 2-2 | | | | |
| Tue 21/08/18 | AFC Blackpool v St Helens Town | 1-0 | | | | |
| Mon 27/08/18 | Chadderton v St Helens Town | 3-2 | | | | |
| Sat 15/09/18 | St Helens Town v Cleator Moor Celtic | 1-3 | | | | |
| Sat 22/09/18 | St Helens Town v Holker Old Boys | 9-0 | | | | |
| Sat 29/09/18 | St Helens Town v Steeton | 4-6 | | | | |
| Thu 04/10/18 | St Helens Town v AFC Liverpool | 3-3 | | | | |
| Sat 06/10/18 | Cheadle Heath Nomads v St Helens Town | 5-2 | | | | |
| Tue 09/10/18 | Prestwich Heys v St Helens Town | 2-2 | | | | |
| Sat 13/10/18 | St Helens Town v Daisy Hill | 4-2 | |  | | |
| Sat 20/10/18 | St Helens Town v Cheadle Town | 0-2 | | | | |
| Tue 23/10/18 | Prescot Cables v St Helens Town | 3-1 | | | | |
| Sat 27/10/18 | Longridge Town v St Helens Town | 5-1 | | | | |
| Thu 01/11/18 | St Helens Town v Prestwich Heys | 1-2 | | | | |
| Sat 17/11/18 | St Helens Town v Carlisle City | 0-2 | | | | |
| Sat 24/11/18 | Daisy Hill v St Helens Town | 0-5 | | | | |
| Wed 28/11/18 | Avro v St Helens Town | 3-1 | | | | |
| Sat 01/12/18 | St Helens Town v Shelley | 2-2 | | | | |
| Sat 15/12/18 | St Helens Town v Bacup Borough | 2-6 | | | | |
| Sat 29/12/18 | St Helens Town v Chadderton | 2-4 | | | | |
| Sat 05/01/19 | Cleator Moor Celtic v St Helens Town | 2-1 | | | | |
| Sat 19/01/19 | St Helens Town v Avro | 0-2 | | | | |
| Sat 26/01/19 | AFC Darwen v St Helens Town | 7-1 | | | | |
| Tue 05/02/19 | Ashton Town v St Helens Town | 2-4 | | | | |
