| Sat 06/08/16 | Parkgate v Irlam | 2-1 | | | | |
| Tue 09/08/16 | Bootle v Irlam | 1-2 | | | | |
| Sat 13/08/16 | Irlam v Padiham | 1-1 | |  | | |
| Tue 16/08/16 | Irlam v AFC Liverpool | 3-3 | | | | |
| Sat 20/08/16 | Irlam v Barnoldswick Town | 1-0 | | | | |
| Mon 22/08/16 | Barnton v Irlam | 0-2 | | | | |
| Sat 27/08/16 | Runcorn Linnets v Irlam | 4-1 | | | | |
| Tue 30/08/16 | Irlam v Abbey Hey | 4-3 | | | | |
| Fri 02/09/16 | Irlam v West Didsbury & Chorlton | 0-6 | | | | |
| Tue 06/09/16 | Hanley Town v Irlam | 1-1 | | | | |
| Sat 10/09/16 | Irlam v Selby Town | 1-0 | | | | |
| Fri 16/09/16 | Irlam v Atherton Collieries | 1-1 | | | | |
| Tue 20/09/16 | 1874 Northwich v Irlam | 1-1 | | | | |
| Sat 24/09/16 | Westella & Willerby v Irlam | 0-3 | | | | |
| Tue 27/09/16 | Barnoldswick Town v Irlam | 3-0 | | |  | |
| Sat 01/10/16 | FC Oswestry Town v Irlam | 1-1 | | | | |
| Tue 04/10/16 | Irlam v Salford City | 0-4 | | | | |
| Tue 18/10/16 | Irlam v Bootle | 1-0 | | | | |
| Sat 22/10/16 | Newcastle Benfield v Irlam | 3-1 | | | | |
| Tue 25/10/16 | Irlam v Hanley Town | 2-1 | | | | |
| Sat 29/10/16 | Squires Gate v Irlam | 1-1 | | | | |
| Wed 02/11/16 | AFC Liverpool v Irlam | 3-2 | | | | |
| Sat 05/11/16 | Irlam v 1874 Northwich | 0-1 | | | | |
| Sat 10/12/16 | Ashton Athletic v Irlam | 1-3 | | | |  |
| Mon 26/12/16 | Abbey Hey v Irlam | 2-1 | | | | |
| Fri 30/12/16 | Irlam v Runcorn Linnets | 0-4 | | | | |
| Sat 07/01/17 | Padiham v Irlam | 3-2 | | | | |
| Sat 14/01/17 | Irlam v Congleton Town | 1-1 | | | | |
| Sat 21/01/17 | Irlam v Winsford United | 1-3 | | | | |
| Sat 04/02/17 | Runcorn Town v Irlam | 3-0 | | | | |
| Sat 11/02/17 | Irlam v Nelson | 1-1 | | | | |
| Sat 18/02/17 | Maine Road v Irlam | 2-3 | | | | |
| Sat 04/03/17 | Irlam v AFC Darwen | 1-3 | | | | |
| Tue 14/03/17 | Irlam v Runcorn Town | 2-1 | | | | |
| Sat 25/03/17 | Irlam v Maine Road | 1-0 | | | | |
| Mon 27/03/17 | Winsford United v Irlam | 2-3 | | | | |
| Sat 01/04/17 | Irlam v Barnton | 2-1 | | | | |
| Tue 04/04/17 | Nelson v Irlam | 0-2 | | | | |
| Sat 08/04/17 | Irlam v Ashton Athletic | 1-2 | | | | |
| Tue 11/04/17 | New Mills v Irlam | 0-2 | | | | |
| Sat 15/04/17 | Congleton Town v Irlam | 1-2 | | | | |
| Mon 17/04/17 | Irlam v Cammell Laird 1907 | 0-2 | | | | |
| Sat 22/04/17 | Irlam v New Mills | 1-0 | | | | |
| Sat 29/04/17 | Cammell Laird 1907 v Irlam | 2-5 | | | | |
